The effect of L-glutamic acid and N-acetylcysteine administration on biochemical blood parameters in rats treated with CCl(4)

A toxic organic substance CCl4 is a well known model compound for studying detoxification function of the liver and developing oxidative stress. The goal study was to estimate effect L-glutamic acid (L-Glu) N-acetylcysteine (NAC) administration on rat blood parameters upon effects CCl4. Experimental male Wistar rats were injected intraperitoneally with CCl4, CCl4/L‑Glu group additionally L-Glu (750 mg/kg), CCl4/NAC – NAC (150 CCl4/L-Glu/NAC mg/kg) mg/kg). duration experiment 24 h. Increased level lipid peroxides, TBARS, triacylglycerols, cholesterol decreased glutathione peroxidase, reductase, glutathione-S-transferase activity GSH content observed in treated animals compared control untreated group. When or L-Glu/NAC most studied indicators shown be close These results suggest that above mentioned aminoacids attenuated CCl4-induced stress rats. Keywords: biochemical parameters, dependent enzymes, acid, N-acetylcysteine, stress, tetrachloromethane